《顧小培到底點樣誤導大眾去賣「四寶」》
蘋果日報放蛇的影片以及一眾大學教授訪問都清楚顯示到底顧小培點樣玩弄偽科學,用臨床前第零期的研究去吹噓其「四寶」點樣醫癌症。
為答謝蘋果記者勇敢放蛇的報導,今日我同大家分析下顧小培點樣係Youtube影片透過講解骨質疏鬆去熱情地賣保健品。
首先,如果有follow開我的都知道,我一次又一次重申骨質疏鬆不是小事,老人家寬關節骨折一年內的死亡率高達40%,所以我們必須確保關於骨質疏鬆的資訊是正確無誤的。
顧小培影片大多可拆解為以下pattern
1. #解說疾病時多為正確
每條影片都幾standardized,通常會先俾個病的background和pathophysiology,多數會用一堆醫學和科學用詞(中文+英文),而呢d背景資料大多都正確無誤,令你相信他的解說。
2. #解釋藥物治療時會集中講藥物的副作用和限制
這也是顧小培常見的技巧,先說明藥物的原理,再提及藥物的副作用和限制,如骨質疏鬆藥Bisphosphonate + Denosumab,顧小培會講bisphosphonate會胃痛/Reflux,兩者只能減少骨質疏鬆,未能增加骨質密度。
的確提及藥物的副作用和限制是informed consent時必須要做的事,但顧小培的目的不是informed consent,而是熱情的賣他的「四寶」,一種他從來無講過副作用和限制的「保健品」。
相比起傳統西藥,這些「沒有」副作用和風險的保健品自然吸引得多。
3. #最後總會帶返去講四寶
唔難發現顧小培的指定動作是
a. 西藥有限制(甚至有害)
b. 四寶(e.g. 洋蔥素有效改善病情,這條影片為有效增加骨質密度)
c. 四寶有研所和論文back up
首先a. 顧小培有意或無意忽略嚴重骨質疏鬆病人可以使用的新藥(Teriparatide),這新藥可有效增加骨質密度。這令讀者產生「現有西藥只治標不能治本」的觀感。
接下來再配合一些老鼠的研究(但永遠不會話你聽是老鼠或實驗室研究)去表示保健品可有效增加骨質密度(製造一個治本的錯覺),讀者自然就會蠢蠢欲動去嘗試這產品。
不過,b+c所謂的四寶可增加密度的研究為臨床前研究,只以老鼠作為對象。
無做過大型人類臨床研究,無論是劑量、點食法、食幾多會中毒、食幾多先有效、會不會跟其他藥物衝突等等,全部都未有資料。
顧小培最常見的手法是提供一條Pubmed的link或號碼,叫讀者自行查閱,但當你用心去睇文獻時便會發現他斷章取義,大部分的研究目前都未有臨床價值。
然而,顧小培諮詢時是永遠不會話你聽
4. #從來無提供醫學監察的建議
基本上治療骨質疏鬆時,醫生必須進行醫學監察,例如驗血、DEXA骨質密度檢查、CT骨質密度檢查等等。
驗血要調查的可能是體內
- 維他命D、血鈣、副甲狀腺素水平、肝腎功能甚至荷爾蒙水平等等
因為骨質疏鬆成因眾多,如果不治療導致骨質疏鬆的成因的話,骨質密度只會繼續流失。
點解顧小培沒有作這樣的建議?我留這個空間給大家思考一下
最後,骨質疏鬆並非小事,老人家跌一跌可大可小,只聽顧小培所講單憑連食咩劑量和食幾多可能會中毒的洋蔥素,分分鐘會令你延醫診治,令骨質密度繼續惡化。
***骨質疏鬆的病人因應情況更可能需要進行fall prevention和運動訓練以減低骨折風險
***寬關節骨折可嚴重影響病人往後的生活質素
#向偽科學說不
#病人健康沒有妥協的空間
同時也有10000部Youtube影片,追蹤數超過2,910的網紅コバにゃんチャンネル,也在其Youtube影片中提到,...
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informed consent中文 在 國家衛生研究院-論壇 Facebook 的最佳解答
「Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China(2020/02/07)+中文摘要轉譯」
➥中文摘要轉譯:
截至2/4日,北京報告13例,大多為年輕健康人。症狀輕微且無人死亡。與過去報導一致,健康人感染後預後較佳。
註:初期流行病學易有偏誤,不可推估大流行時狀況。(財團法人國家衛生研究院-郭書辰醫師整理)
➥In December 2019, cases of pneumonia appeared in Wuhan, China. The etiology of these infections was a novel coronavirus (2019-nCoV),1,2 possibly connected to zoonotic or environmental exposure from the seafood market in Wuhan. Human-to-human transmission has accounted for most of the infections, including among health care workers.3,4 The virus has spread to different parts of China and at least 26 other countries.1 A high number of men have been infected, and the reported mortality rate has been approximately 2%, which is lower than that reported from other coronavirus epidemics including severe acute respiratory syndrome (SARS; mortality rate, >40% in patients aged >60 years)5 and Middle East respiratory syndrome (MERS; mortality rate, 30%).6 However, little is known about the clinical manifestations of 2019-nCoV in healthy populations or cases outside Wuhan. We report early clinical features of 13 patients with confirmed 2019-nCoV infection admitted to hospitals in Beijing.
「Methods」
Data were obtained from 3 hospitals in Beijing, China (Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University [8 patients], Beijing Anzhen Hospital, Capital Medical University [4 patients], and College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital [1 patient]). Patients were hospitalized from January 16, 2020, to January 29, 2020, with final follow-up for this report on February 4, 2020. Patients with possible 2019-nCoV were admitted and quarantined, and throat swab samples were collected and sent to the Chinese Center for Disease Control and Prevention for detection of 2019-nCoV using a quantitative polymerase chain reaction assay.3 Chest radiography or computed tomography was performed. Data were obtained as part of standard care. Patients were transferred to a specialized hospital after diagnosis. This study was approved by the ethics commissions of the 3 hospitals, with a waiver of informed consent.
「Results」
The median age of the patients was 34 years (25th-75th percentile, 34-48 years); 2 patients were children (aged 2 years and 15 years), and 10 (77%) were male. Twelve patients either visited Wuhan, including a family (parents and son), or had family members (grandparents of the 2-year-old child) who visited Wuhan after the onset of the 2019-nCoV epidemic (mean stay, 2.5 days). One patient did not have any known contact with Wuhan.
Twelve patients reported fever (mean, 1.6 days) before hospitalization. Symptoms included cough (46.3%), upper airway congestion (61.5%), myalgia (23.1%), and headache (23.1%) (Table). No patient required respiratory support before being transferred to the specialty hospital after a mean of 2 days. The youngest patient (aged 2 years) had intermittent fever for 1 week and persistent cough for 13 days before 2019-nCoV diagnosis. Levels of inflammatory markers such as C-reactive protein were elevated, and numbers of lymphocytes were marginally elevated (Table).
Four patients had chest radiographs and 9 had computed tomography. Five images did not demonstrate any consolidation or scarring. One chest radiograph demonstrated scattered opacities in the left lower lung; in 6 patients, ground glass opacity was observed in the right or both lungs (Figure). As of February 4, 2020, all the patients recovered, but 12 were still being quarantined in the hospital.
➥Author: De Chang, Minggui Lin, Lai Wei, et al.
➥Link: (JAMA) https://jamanetwork.com/journals/jama/fullarticle/2761043
衛生福利部
疾病管制署 - 1922防疫達人
疾病管制署
國家衛生研究院-論壇
#2019COVID19Academic
informed consent中文 在 國家衛生研究院-論壇 Facebook 的最佳解答
「Epidemiologic and Clinical Characteristics of Novel Coronavirus Infections Involving 13 Patients Outside Wuhan, China(2020/02/07)+中文摘要轉譯」
➥中文摘要轉譯:
截至2/4日,北京報告13例,大多為年輕健康人。症狀輕微且無人死亡。與過去報導一致,健康人感染後預後較佳。
註:初期流行病學易有偏誤,不可推估大流行時狀況。(財團法人國家衛生研究院-郭書辰醫師整理)
➥In December 2019, cases of pneumonia appeared in Wuhan, China. The etiology of these infections was a novel coronavirus (2019-nCoV),1,2 possibly connected to zoonotic or environmental exposure from the seafood market in Wuhan. Human-to-human transmission has accounted for most of the infections, including among health care workers.3,4 The virus has spread to different parts of China and at least 26 other countries.1 A high number of men have been infected, and the reported mortality rate has been approximately 2%, which is lower than that reported from other coronavirus epidemics including severe acute respiratory syndrome (SARS; mortality rate, >40% in patients aged >60 years)5 and Middle East respiratory syndrome (MERS; mortality rate, 30%).6 However, little is known about the clinical manifestations of 2019-nCoV in healthy populations or cases outside Wuhan. We report early clinical features of 13 patients with confirmed 2019-nCoV infection admitted to hospitals in Beijing.
「Methods」
Data were obtained from 3 hospitals in Beijing, China (Beijing Tsinghua Changgung Hospital, School of Medicine, Tsinghua University [8 patients], Beijing Anzhen Hospital, Capital Medical University [4 patients], and College of Respiratory and Critical Care Medicine, Chinese PLA General Hospital [1 patient]). Patients were hospitalized from January 16, 2020, to January 29, 2020, with final follow-up for this report on February 4, 2020. Patients with possible 2019-nCoV were admitted and quarantined, and throat swab samples were collected and sent to the Chinese Center for Disease Control and Prevention for detection of 2019-nCoV using a quantitative polymerase chain reaction assay.3 Chest radiography or computed tomography was performed. Data were obtained as part of standard care. Patients were transferred to a specialized hospital after diagnosis. This study was approved by the ethics commissions of the 3 hospitals, with a waiver of informed consent.
「Results」
The median age of the patients was 34 years (25th-75th percentile, 34-48 years); 2 patients were children (aged 2 years and 15 years), and 10 (77%) were male. Twelve patients either visited Wuhan, including a family (parents and son), or had family members (grandparents of the 2-year-old child) who visited Wuhan after the onset of the 2019-nCoV epidemic (mean stay, 2.5 days). One patient did not have any known contact with Wuhan.
Twelve patients reported fever (mean, 1.6 days) before hospitalization. Symptoms included cough (46.3%), upper airway congestion (61.5%), myalgia (23.1%), and headache (23.1%) (Table). No patient required respiratory support before being transferred to the specialty hospital after a mean of 2 days. The youngest patient (aged 2 years) had intermittent fever for 1 week and persistent cough for 13 days before 2019-nCoV diagnosis. Levels of inflammatory markers such as C-reactive protein were elevated, and numbers of lymphocytes were marginally elevated (Table).
Four patients had chest radiographs and 9 had computed tomography. Five images did not demonstrate any consolidation or scarring. One chest radiograph demonstrated scattered opacities in the left lower lung; in 6 patients, ground glass opacity was observed in the right or both lungs (Figure). As of February 4, 2020, all the patients recovered, but 12 were still being quarantined in the hospital.
➥Author: De Chang, Minggui Lin, Lai Wei, et al.
➥Link: (JAMA) https://jamanetwork.com/journals/jama/fullarticle/2761043
衛生福利部
疾病管制署 - 1922防疫達人
疾病管制署
國家衛生研究院-論壇
#2019COVID19Academic
informed consent中文 在 吳欣岱- 今天想談談#積極同意。跟醫療行為上常常講到的知情 ... 的推薦與評價
跟醫療行為上常常講到的知情同意(informed consent)有點像但不太一樣,這個名詞 ... 之前性騷擾事件鬧得沸沸揚揚的時候,有熱心的網友傳給我這段他們特地加上中文字幕 ... ... <看更多>