[關於反芻動物全身麻醉的風險,反芻動物中,全身麻醉的弊大於利。] 有興趣的朋友可以多了解一下喔! (中文翻譯的部分為Google翻譯的,能夠閱讀英文的朋友建議看原文會比較清楚喔)
還有很多很多相關的學術發表,就不貼那麼多出來啦!
Cooper結紮的日期是4月26日,他現在很健康很調皮。
(德叔真的超級超級愛看這些學術發表的文章,但是我還是相信醫生的專業。)
https://www.researchgate.net/publication/334673867_The_Use_of_Epidural_Anaesthesia_over_General_Anaesthesia_in_Ruminants
全身麻醉是現代醫學的重要組成部分。它是一種藥物誘導的可逆病症,包括特定的行為和生理特徵,包括無意識、健忘症、鎮痛和運動不能——伴隨自主神經、心血管、呼吸和體溫調節系統的穩定性。
[反芻動物全身麻醉具有內在風險,如瘤胃內容物反流、唾液分泌過多和肺部誤吸的可能性;因此並不總是推薦使用本地或區域技術。硬膜外麻醉是一種中樞神經阻滯技術,經常用於獸醫實踐中,用於治療家畜會陰、骶骨、腰椎和尾椎部位的不同產科和外科手術干擾。關於在反芻動物和其他物種的各種外科和實驗室程序中使用硬膜外麻醉的科學研究已經有幾項。總之,全身麻醉的弊大於利,特別是在反芻動物中。因此,硬膜外麻醉是首選。
General anaesthesia is an essential component of modern medicine. It is a drug induced reversible condition that includes specific behavioral and physiological traits unconsciousness, amnesia, analgesia, and akinesia- with concomitant stability of the autonomic, cardiovascular, respiratory, and thermoregulatory systems.
[General anesthesia in ruminants has inherent risks such as regurgitation of ruminal contents, excessive salivation and the possibility of pulmonary aspiration; therefore it is not always recommended and local or regional techniques may be used instead. Epidural anaesthesia is a central neuraxial block technique which is used regularly in veterinary practice for treatment of different obstetrical and surgical interferences in the perineal, sacral, lumbar, and caudal parts of the thoracic region of domestic animals. There have been several scientific researches on the use of epidural anesthesia in ruminants and other species for various surgical and laboratory procedures. In conclusion, the disadvantages of general anaesthesia outweigh the advantages especially in ruminant specie. Therefore, epidural anaesthesia is the most preferred.
https://onlinelibrary.wiley.com/doi/abs/10.1002/9781118886700.ch1
瘤胃鼓脹、腹脹、反流和吸入性肺炎是與家畜全身麻醉相關的常見問題,應通過適當的預防措施和必要的麻醉前考慮來預見和解決。家畜在麻醉期間可能會出現胃內容物反流和誤吸,尤其是未禁食的動物。反芻動物在麻醉期間通常會大量分泌唾液。惡性高熱的觸發因素包括壓力(例如興奮、運輸或麻醉前處理)、鹵化吸入麻醉劑(例如氟烷、異氟烷、七氟烷和地氟烷)和去極化神經肌肉阻滯藥物(例如琥珀膽鹼)。同樣,氟烷似乎是豬惡性高熱的最有效和最常見的觸發因素。麻醉前禁食可能不能完全防止反流,但會減少瘤胃內容物中的固體物質數量。獸醫應將這些知識與適當的麻醉前準備和適當的圍手術期管理相結合,以確保這些動物的麻醉成功。
Ruminal tympany, bloat, regurgitation, and aspiration pneumonia are common problems associated with general anesthesia in farm animal species that should be anticipated and addressed with proper precautions and the necessary preanesthetic considerations. Regurgitation and aspiration of stomach content can occur in farm animal species during anesthesia, especially in nonfasted animals. Ruminants normally salivate profusely during anesthesia. The triggering agents of malignant hyperthermia include stress (e.g., excitement, transportation, or preanesthetic handling), halogenated inhalation anesthetics (e.g., halothane, isoflurane, sevoflurane, and desflurane), and depolarizing neuro-muscular blocking drugs (e.g., succinylcholine). Similarly, halothane appears to be the most potent and most frequently reported trigger of malignant hyperthermia in pigs. Preanesthetic fasting may not completely prevent regurgitation, but it will decrease the amount of solid matter in the rumen content. Veterinarians should incorporate the knowledge with proper preanesthetic preparations and appropriate perioperative management to ensure successful outcome of anesthesia in these animals.
同時也有10000部Youtube影片,追蹤數超過2,910的網紅コバにゃんチャンネル,也在其Youtube影片中提到,...
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🌻[新書介紹]"從0開始打造財務自由的致富系統:暢銷10年經典「系統理財法」,教你變成有錢人"
這陣子一些個股的飆法, 是不是讓您覺得賺錢很容易呢? 這並不是常態, 所以正確的投資與理財觀念很重要. 也請不要認為這樣(買這些飆股)能一夕致富喔.
今天要介紹的一本書, 就是作者藉由分享自己的理財方式, 希望讀者能夠參考自己的方法, 來有系統地打造一個理財計劃.
我年紀不小了, 所以不是這本書的主要目標族群😅, 不過倒挺建議剛入社會, 或是年輕人看看, 說不定會從裡面得到一些啟發. 你不理財, 才不理你. 如果能從年輕時開始擬定適合自己的理財計劃, 並養成習慣, 好好執行, 那財富指日可待!
柏客來網站:
https://www.books.com.tw/products/0010882103?loc=P_0004_053
🌻Fidelity Contrafund的Will Danoff訪談摘要
很扎實, 有內容的一篇訪談. 雖然不少內容都已經在自己的實作上了, 但有從他的談話中應證了以前的一些想法, 於是還是整理了一下筆記(不過也不是完全100%同意他的觀點就是(有寫在下方))
https://makingsenseofusastocks.blogspot.com/2021/01/fidelity-contrafundwill-danoff.html
🌻Microsoft(MSFT)財報結果
節錄CNBC的重點:
1. Azure revenue growth accelerated and came in above analysts’ expectations for the quarter.
2. Sales of new Xbox consoles didn’t hurt the margin of the Windows business as much as analysts had expected.
3. Revenue guidance for the company quarter beat expectations.
CEO的話:「過去1年裡,我們見證了席捲每家公司和每個行業的第2波數位化轉型的曙光。」
(中文文字來源: https://tw.appledaily.com/property/20210127/YQPVSZAXC5HV5GFAWVZACAT5QQ/)
原文: What we are witnessing is the dawn of a second wave of digital transformation sweeping every company and every industry. Digital capability is key to both resilience and growth. It's no longer enough to just adopt technology. Businesses need to build their own technology to compete and grow. Microsoft is powering this shift with the world's largest and most comprehensive cloud platform.
官方財報新聞稿連結: https://www.microsoft.com/en-us/Investor/earnings/FY-2021-Q1/press-release-webcast
🌻沒太follow ARK的新聞, 不過最近連續有三個媒體在報導. 這些基金對我來說, 算是動能投資的操作方式. 若碰到修正, 會拉回很多. 供參.
https://www.cnbc.com/2021/01/22/cramer-worries-about-investors-mimicking-ark-invests-cathie-wood.html
https://www.barrons.com/articles/ark-etfs-might-be-too-popular-for-their-own-good-51611234009
https://www.wsj.com/articles/the-story-behind-the-markets-hottest-funds-thematic-etfs-arkg-vegn-11610722419
🌻關於SPAC
高盛:美股的確已有泡沫現象 SPAC火熱
https://news.cnyes.com/news/id/4562981
GS的CEO在財報上也有提到SPAC: Goldman Sachs warned of the risks in SPACs"I do think SPACs is a good use case, versus a traditional IPO, and advantages for sellers and for investors and looking at this ecosystem. But the ecosystem is not without flaws. I think it's still evolving. I think the incentive system is still evolving. One of the things we're watching very, very closely is the incentives of the sponsors, and also the incentives of somebody that selling. And while I think these activity levels continue to be very robust, and that they do continue as we head into 2021 continue to be very, very robust. I do not think this is sustainable in the medium term...things I certainly think is the case is you have something here it's a good capital markets innovation. But like many innovations, there's a point in time as they start, where they have a tendency, maybe to go a little bit too far, and then need to be pulled back or rebalanced in some way. And that's something my guess is we'll see over the course of 2021 or 2022, with SPAC" - Goldman Sachs (GS) CEO David Solomon
Pictures來源: 出版社提供; https://www.cnbc.com/2021/01/26/microsoft-msft-earnings-q2-2021.html
advantages中文 在 小虎.fip腹膜炎gs441524治療日記 Facebook 的最佳解答
【瑞德西韋vs貓FIP傳染性腹膜炎】英國和澳洲開始試用Remdesivir GS5734治療FIP貓。
1)價格:10mg/ml,每瓶100mg/10ml
價格是$250(不知道是美元還是澳幣,有說美元$600/20ml)
#每ml只含10mg濃度,即是意味著注射量要比GS441更多⋯假使貓打GS441是1.5ml,那麼瑞德西韋要打2.25ml。如果正在注射2.5ml GS44的大貓,就要注射多達3.75ml瑞德西韋。
#有研究報告指瑞德西韋抑制Mers/Sars的能力是GS441的3-10倍。但Dr Pedersen回覆小虎時認為此說法「不正確」。
2)劑量:兩國研究者同時咨詢Dr Pedersen意見,得到的回覆跟小虎得到的一樣:兩者劑量基本等效:
5-6mg 普通病例起跳
8mg 眼部病變起跳
10mg 神經病變起跳
3)療效:據說有效,實驗貓反饋不錯。(不過小虎認為最好觀察更多臨床實驗報告)
#另外最近有美國研究指GS441對Covid肺炎症狀的治療比瑞德西韋更佳,並提倡美國FDA審批使用GS441治療人類新冠肺炎。這是否意味著面對胸水型FIP,GS441更具優勢?《Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment》https://pubs.acs.org/doi/10.1021/acsmedchemlett.0c00316
4)腎細胞毒性
這些研究者沒有回應有關查詢。
Dr Pedsersen曾經回覆小虎指,瑞德西韋用量跟GS441一樣,但瑞德西韋在人體使用有發現少量肝腎毒性,暫時不知在貓身上毒性水平如何,未知安全性是否及得上GS441。
#過去曾經有針對Mers病毒的臨床實驗研究報告指瑞德西韋的毒性比GS441高。
Treatment of FIP in cats with Remdesivir:
http://www.vetqml.com.au/Portals/0/PDF/Publications/Treatment%20of%20FIP%20with%20Remdesevir.final.pdf
大家的貓貓如果中招有了FIP,可以加入這些群組求救和查詢:
【香港:FIP 腹膜炎 (最新資訊) 治療群組】https://www.facebook.com/groups/fipcatvirushk/
【海外:FIP Warriors群組】
https://www.facebook.com/groups/804374446995270
美國西部/加州FIP群組:https://www.facebook.com/groups/500835247226864/
加拿大FIP群組:https://www.facebook.com/groups/944659292587855/
台灣FIP互助群組:https://www.facebook.com/groups/taiwanfip/
澳洲Warrior群組:https://www.facebook.com/groups/756012691580159
藥商消息:
【各間GS441藥商的歷史和評價】:https://bit.ly/2Y6zxql
【FIP大新聞:注意劣質藥】:https://bit.ly/2RJvTy1
【貓腹膜炎新藥KP-01?不要亂試】:https://bit.ly/3kAbQ1I
【冒牌藥注意:小栗子】https://bit.ly/3mwlK4V
【劣質GS441:傳腹停】https://bit.ly/3henmz3
延伸閱讀:
【Pedersen最新談瑞德西韋對FIP的潛力】
中文版:https://xw.qq.com/cmsid/20200322A0GTBF00
英文原文:https://sockfip.org/2020-dr-pedersen-gs-441524-update/
腹膜炎病毒如何突變而來?貓需要隔離嗎:http://bit.ly/38TFhWE
FIP貓可以絕育嗎:http://bit.ly/2wzrhDA
認識GS441是什麼:http://bit.ly/38cqWUO
口服 vs 打針,打針會更有效:http://bit.ly/2ZWpwhr
GS441治療為何會復發?九大原因:https://bit.ly/36ygMAp
小虎的營養品清單:http://bit.ly/2NNkbBm
恐怖的fip腹膜炎腦神經病變:http://bit.ly/2Qt7uNj
小虎6月5日確診病徵記錄:http://bit.ly/2HQMYlo
第一周441治療救命記錄:http://bit.ly/2HQxKg5
透過mRNA檢測輔助停針:http://bit.ly/2MGg34f
濫用GS441會導致災難:http://bit.ly/2TKSZFf
甚麼是 #FIP:http://bit.ly/2NOtEc6(中譯:http://bit.ly/2NLvJFO)
#GS441524 病毒抑制劑研究報告:http://bit.ly/2XEemN4、http://bit.ly/2JzCsib(中文版:http://bit.ly/2JZLaGU)
治療嚴重的眼部腦部病變:http://bit.ly/2SosZAA、http://bit.ly/2Zb71jW
腹膜炎的一切知識:http://bit.ly/2HPPKab
看懂驗血報告:http://bit.ly/2HgXulr(中文:http://bit.ly/2ZmUdHp)
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