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#1. Wnt signaling in cancer - PubMed
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer. The role of Wnt signaling in ...
#2. Wnt signaling in cancer | Oncogene - Nature
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer.
#3. The Wnt signaling pathway in tumorigenesis, pharmacological ...
Here, we review the role of Wnt signaling in cancer development in associated organs ... Cao B, Yang W, Jin Y, Zhang M, He T, Zhan Q, et al.
#4. An update on Wnt signaling pathway in cancer - Zhang
The Wnt signaling pathway is critical for the regulation of cell proliferation, differentiation, apoptosis and migration. Mutations in the Wnt gene or Wnt ...
#5. WNT Signaling in Tumors: The Way to Evade Drugs and ...
This pathway should be a main target in cancer therapy as WNT signaling activation is essential for tumor progression and survival, even in the ...
#6. Wnt Signaling in Cancer: Not a Binary ON:OFF Switch
Wnt signaling can promote invasion of cancer cells by regulating genes involved in cell adhesion, including Eph/Ephrins and E-cadherin (35). Several matrix ...
#7. Wnt Signaling and Drug Resistance in Cancer
Many of the reported noncoding RNAs confer stemness traits to cancer cells through activating Wnt/β-catenin signaling (Zhan et al., 2017).
#8. The Wnt Signalling Pathway: A Tailored Target in Cancer - MDPI
The Wnt ligands bind to frizzled (FZD) receptor and the low-density-lipoprotein-related protein 5/6 (LRP5/LRP6); this results in dishevelled (DVL) ...
#9. Metabolic balance in colorectal cancer is maintained by ...
Canonical Wnt signaling is hyperactivated in many human ... 50 percent of tumors; Cancer Genome Atlas Network, 2012; Zhan et al, 2017).
#10. Wnt Signaling in Cancer | SpringerLink
The Wnt/β-catenin-dependent canonical pathway is the most comprehensively ... Zhan T, Rindtorff N, Boutros M (2017) Wnt signaling in cancer.
#11. Wnt pathway in oral cancer: A review update - ScienceDirect
Studies about the Wnt pathway have unfolded its regulation in many cancer ... and non-canonical type (β-catenin independent) signalling (Zhan et al., 2017).
#12. Role of the Wnt Signaling Pathway and Lung Cancer
Four signaling pathways are typically described for Wnt proteins. The canonical Wnt-β catenin pathway, through which β-catenin dependent activity occurs, the ...
#13. Wnt signaling in cancer - University at Albany
Wnt signaling in cancer. ; Zhan, T ; Rindtorff, N ; Boutros, M ...
#14. TIM-3 signaling hijacks the canonical Wnt/β-catenin pathway ...
To hijack canonical Wnt pathway, HCK and p120-cate. ... Zhan. T. ,. Rindtorff. N. ,. Boutros. M . Wnt signaling in cancer.
#15. Overview of clinical trials with drugs targeting the Wnt pathway
All depicted drugs are currently undergoing testing in Phase 1/2 against various types of cancer (see also Table 1). Wnt signaling in cancer T Zhan et al ...
#16. WNT signaling and cancer stemness | Essays in Biochemistry
The WNT signaling network orchestrates the functions of cancer-associated fibroblasts, endothelial cells and immune cells in the tumor ...
#17. Wnt pathway modulators in cancer therapeutics: An update on ...
Abstract Wnt signaling plays an essential role in the initiation and ... ROR1R-CAR-T, ROR1, Breast cancer, leukemia, lymphoma and nonsmall ...
#18. Wnt signaling pathway - Wikipedia
The Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell surface ...
#19. Wnt signalling in stem cells and cancer
Wnt pathway is integrally involved in both stem cell and cancer cell maintenance and ... Conditional deletion of b-catenin (lck-driven) T-cell progenitors.
#20. Wnt Signaling as a Master Regulator of Immune Tolerance in ...
Aberrant Wnt signaling is a hallmark of many cancer types such as colon cancer. ... the activation of canonical Wnt signaling in dendritic cells promoting T ...
#21. Pharmacological Wnt ligand inhibition overcomes key tumor ...
Wnt signaling drives kynurenine production and PMN-MDSC ... across cancer types and suppress anti-tumor CD8+ T cell re-.
#22. Wnt signaling activation: targets and therapeutic opportunities ...
While aberrant Wnt signaling contributes to diseases such as cancer, activation of Wnt/β-catenin signaling is a target of interest in stem ...
#23. Wnt Signaling Pathway - Creative Biolabs
Zhan, T., N. Rindtorff, and M. Boutros. "Wnt signaling in cancer." Oncogene 36.11 (2017): 1461. For research use only. Not ...
#24. [PDF] Wnt signaling in cancer | Semantic Scholar
Current insights into novel components of Wnt pathways are reviewed and how Wnt signaling affects maintenance of cancer stem cells, ...
#25. Wnt Signaling and Plasticity of Lung Cancer Cells | EJMO 2022
The Wnt signaling pathway can sustain these CS-LCs with β-Cat present in ... Shaurova T, Zhang L, Goodrich DW, Hershberger PA. Under-.
#26. Wnt signaling and hepatocarcinogenesis: Molecular targets ...
Hepatocellular carcinoma (HCC) is one of the most common causes of cancer death worldwide. HCC can be cured by radical therapies if early ...
#27. Canonical Wnt / β-Catenin Signaling - Sigma-Aldrich
Components of Wnt pathway are frequently mutated (Table 2), which implicates its role cancer progression. Mutation, Protein, Disease. Gain of ...
#28. New Advances in Classical Wnt/β-Catenin Signaling in Cancer
Wnt /?-catenin-mediated signaling is a key pathway regulating tissue growth and development and tumorigenesis. This signaling pathway has ...
#29. An Updated Overview on Wnt Signaling Pathways
Wnt Proteins Activate Apparently Distinct Signaling Pathways ... The role of beta-catenin in cell adhesion, signal transduction, and cancer.
#30. Canonical and non-canonical WNT signaling in cancer stem ...
Cancer stem cells (CSCs), which have the potential for self-renewal, ... Zhan T, Rindtorff N and Boutros M: Wnt signaling in cancer.
#31. WNT and β-Catenin in Cancer: Genes and Therapy
The WNT pathway is commonly mutated in many cancers, leading to widespread ... ... Once in the nucleus, β-catenin binds to the transcription factors T cell ...
#32. Wnt signalling: conquering complexity | Development
Frequent alteration of Wnt pathway members in human cancers. In silico analysis of selected datasets from The Cancer Genome Atlas (TCGA) for ...
#33. Targeting the Wnt signalling pathway in cancer: prospects and ...
The Wnt pathway, involved in cancer development and progression, ... Reya T, Clevers H. Wnt signalling in stem cells and cancer. Nature.
#34. The role of the Wnt signaling pathway in cancer stem cells
In addition to classical “canonical” Wnt activation of β-catenin/T-cell factor (TCF) transcriptional complexes, Wnt proteins can elicit a ...
#35. Wnt signaling pathway and its role in cancer and ... - YouTube
Your browser can' t play this video. Learn more. Switch camera ... Wnt signaling pathway and its role in cancer and patterning of the brain.
#36. Targeting Wnt signaling in colorectal cancer. A Review in the ...
Wnt signaling has also been implicated in a variety of cancers and other diseases. ... In the nucleus, β-catenin displaces the repressor Groucho from T cell ...
#37. A novel β-catenin/BCL9 complex inhibitor blocks oncogenic ...
In many of these cancers, dysregulated Wnt signaling is associated ... binds to DNA through T cell factor (TCF)/lymphoid enhancing factor ...
#38. The Role of WNT Signaling in Mature T Cells - AAI Journals
Abstract. T cell factor, the effector transcription factor of the WNT signaling pathway, was so named because of the primary observation ...
#39. Wnt Signaling and Epithelial-Mesenchymal Transition ...
Cancer Genomics. Proteomics 15: 127-141. 13. Zhang J, Cai H, Sun L, Zhan P, Chen M, et al. (2018) LGR5, a ...
#40. Wnt Signaling Pathway in Non–Small Cell Lung Cancer | JNCI
This permits cytoplasmic accumulation of β-catenin, from where it can move to the nucleus to bind with T-cell factor (TCF), lymphoid enhancer-binding factor ( ...
#41. Cross-Talk between p53 and Wnt Signaling in Cancer
Xiao Q, Werner J, Venkatachalam N, Boonekamp KE, Ebert MP, Zhan T. Biomolecules. 2022 Mar 15;12(3):453. doi: 10.3390/biom12030453.
#42. The Role of Wnt Signaling in Cancer | Technology Networks
Wnt signaling is an evolutionarily conserved regulatory pathway that governs numerous normal cellular and developmental processes such as cell ...
#43. Wnt signaling: A complex issue - SciELO Chile
In adults, Wnts function in homeostasis, and inappropriate activation of the Wnt pathway is implicated in a variety of cancers. Wnt-Receptors. Wnt ligands ...
#44. Signaling by WNT in cancer - Reactome Pathway Database
PubMed ID Title Journal Year 10700176 Nat. Genet. 2000 22438566 Wnt signaling in cancer. Polakis, P Cold Spring Harb Perspect Biol 2012
#45. MCE-生物活性分子大师| 抑制剂-化合物库-重组蛋白
MCE (MedChemExpress) 为生命科学和医药研发人员提供50000+ 特异性抑制剂、化合物库、重组蛋白，专注于信号通路和疾病研究领域。全球文献广泛引用，质控体系严格，100% ...
#46. 科学家在癌症生物标志物研究领域取得的重要研究成果！ - 生物谷
近日，来自哈佛医学院医学与癌症中心医学部血液肿瘤科的研究者们在Cancer Research杂志上发表了题为“WNT5a Signaling through ROR2 Activates the Hippo ...
#47. Definition of Wnt signaling pathway inhibitor SM08502
This decreased expression of Wnt pathway-related genes prevents Wnt signaling and may inhibit proliferation of cancer cells in which the Wnt signaling pathway ...
#48. Stabilisation of β-Catenin-WNT signalling by USP10 in APC ...
Stabilisation of β-Catenin-WNT signalling by USP10 in APC-truncated colorectal cancer drives cancer stemness and enables super-competitor ...
#49. Natural Products as Less Toxic Antitumoral/Antiangiogenic ...
Zhan T, Rindtorff N, Boutros M. Wnt Signaling in Cancer. Oncogene (2017) 36(11):1461-73. doi: 10.1038/onc.2016.304 94. Kim EK, Choi EJ.
#50. Early Detection and Diagnosis of Cancer - 第 55 頁 - Google 圖書結果
Inhibition of SOX17 by microRNA 141 and methylation activates the WNT signaling pathway in esophageal cancer. J. Mol. Diagn. 14, 577–585. doi: 10.1016/j.
#51. Cancer Cell Metabolism and Immunomodulation in the Context ...
The GSK3 Signaling Axis Regulates Adaptive Glutamine Metabolism in Lung Squamous Cell Carcinoma. Cancer Cell (2018) 33:905-21.e5. doi: 10.1016/ ...
#52. Oncogenomics: From Basic Research to Precision Medicine
Cancer stem cells--perspectives on current status and future directions: ... Illegitimate WNT signaling promotes proliferation of multiple myeloma cells.
#53. Genomic alteration landscapes of aging, metabolic disorders, ...
Inhibition of PRRX2 suppressed colon cancer liver metastasis via inactivation of Wnt/β-catenin signaling pathway. Pathol. Res. Pract.
#54. Biomarkers in Genitourinary Cancers: Volume I
Song T, Zhang X, Wang C, Wu Y, Dong J, Gao J, et al. ... to the development of bladder cancer via regulating miR-98/STAT3/Wnt/β-catenin pathway axis.
#55. Biomarkers of the Tumor Microenvironment - 第 87 頁 - Google 圖書結果
Proteoglycans in cancer biology, tumour microenvironment and angiogenesis. ... of cell surface heparan sulfate proteoglycans to promote Wnt signaling.
#56. Degroot's Endocrinology, E-Book - 第 952 頁 - Google 圖書結果
Cancer -associated hypercalcaemia in squamous-cell malignancies: a survival and ... The role of the Wnt-signaling antagonist DKK1 in the development of ...
#57. La curcumine affame les cellules cancéreuses jusqu'à la mort
Cette étude a jeté une nouvelle lumière sur la capacité de la curcumine à affamer le cancer pour le soumettre en interférant avec la façon dont ...
wnt signaling in cancer t zhan 在 Wnt signaling pathway and its role in cancer and ... - YouTube 的推薦與評價
Your browser can' t play this video. Learn more. Switch camera ... Wnt signaling pathway and its role in cancer and patterning of the brain. ... <看更多>