Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein. Yeast Rap1 protects telomeres from non-homologous ... ... <看更多>
「rap1 telomere」的推薦目錄：
rap1 telomere 在 Telomere-dependent and telomere ... - Springer Link 的相關結果
RAP1 regulates telomeres by directly binding to double-stranded telomeric DNA (budding yeast) or interacting with a group of homologs consisting ... ... <看更多>
rap1 telomere 在 The Human Rap1 Protein Complex and Modulation of ... 的相關結果
hRap1 is the human homologue of yeast RAP1. In yeast, RAP1 is a negative regulator of telomere length as well as a regulator of transcription (for review, ... ... <看更多>
rap1 telomere 在 Rap1 prevents telomere fusions by nonhomologous end joining 的相關結果
Telomeres protect chromosomes from end-to-end fusions. In yeast Saccharomyces cerevisiae, the protein Rap1 directly binds telomeric DNA. Here, we use a new ... ... <看更多>
rap1 telomere 在 DNA binding modes influence Rap1 activity in the regulation ... 的相關結果
Crystal structures have shown that Rap1DBD binds telomere repeat DNA in a sequence‐specific fashion through both the Myb-like motifs, which make ... ... <看更多>
rap1 telomere 在 Rif2 protects Rap1-depleted telomeres from MRX ... - eLife 的相關結果
Rap1 is the main protein that binds double-stranded telomeric DNA in Saccharomyces cerevisiae. Examination of the telomere functions of Rap1 ... ... <看更多>
rap1 telomere 在 RAP1 Protein Interacts with Yeast Telomeres In Vivo - Cell Press 的相關結果
RAP1 Protein Is Bound to Telomeric Chromatin. RAP1 binds to naked telomeric DNA in vitro as assayed by gel retardation and nitrocellulose binding experiments. ( ... ... <看更多>
rap1 telomere 在 Full article: Decoding telomere protein Rap1 的相關結果
Mammalian Rap1, the most conserved telomere-interacting protein, beyond its role within nucleus for the maintenance of telomeric functions, ... ... <看更多>
rap1 telomere 在 Rap1 protein regulates telomere turnover in yeast - PNAS 的相關結果
In addition, combining the rap1-ΔC mutation with a telomerase template mutation (ter1-kpn), which directs the addition of mutated telomeric DNA repeats to ... ... <看更多>
rap1 telomere 在 Telomere protein Rap1 is a charge resistant scaffolding ... 的相關結果
Chromosomes reorganize in early meiotic prophase to form the so-called telomere bouquet. In fission yeast, telomeres localize to the nuclear ... ... <看更多>
rap1 telomere 在 Telomere-binding proteins Taz1 and Rap1 regulate ... - PLOS 的相關結果
Telomere -binding proteins Taz1 and Rap1 regulate DSB repair and suppress gross chromosomal rearrangements in fission yeast. ... <看更多>
rap1 telomere 在 A genetic interaction between RAP1 ... - Wiley Online Library 的相關結果
Summary RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres, although its role in telomere ... ... <看更多>
rap1 telomere 在 Telomere protein RAP1 levels are affected by cellular aging ... 的相關結果
The telomere length is normally maintained in embryonic cells and stem ... RAP1 is recruited to telomeric repeats by TRF2, and in mouse ... ... <看更多>
rap1 telomere 在 A RAP1-interacting protein involved in transcriptional ... 的相關結果
Strains carrying gene disruptions of RIF1 grow normally but are defective in transcriptional silencing and telomere length regulation, two phenotypes strikingly ... ... <看更多>
rap1 telomere 在 RAP1 | SGD - Saccharomyces Genome Database 的相關結果
Rap1p is the major double-stranded telomeric repeat-binding protein in budding yeast and has essential roles in telomere length regulation, subtelomeric gene ... ... <看更多>
rap1 telomere 在 Investigation into the role of human RAP1 in telomere protection 的相關結果
Second, RAP1 downregulation in replicative senescent cells leads to telomere fusions and DNA damage response activation. This is consistent with similar ... ... <看更多>
rap1 telomere 在 Rap1 Affects the Length and Heterogeneity of Human ... 的相關結果
Because the human Rap1 ortholog hRap1 does not bind to telomeric DNA directly but is recruited to telomeres by TRF2, we examined its role in telomere length ... ... <看更多>
rap1 telomere 在 探討Rap1蛋白質磷酸化在端粒的功能 的相關結果
1. Conrad, M.N., et al., RAP1 protein interacts with yeast telomeres in vivo: overproduction alters telomere structure and decreases chromosome stability. Cell, ... ... <看更多>
rap1 telomere 在 Decoding telomere protein Rap1 - CORE 的相關結果
Decoding telomere protein Rap1: Its telomeric and nontelomeric functions and potential implications in diabetic cardiomyopathy. Yin Caia,†. ... <看更多>
rap1 telomere 在 PomBase - protein coding gene - rap1 (SPBC1778.02) 的相關結果
02) - shelterin complex telomere binding subunit Rap1. Welcome to PomBase. A comprehensive database for the fission yeast Schizosaccharomyces pombe, providing ... ... <看更多>
rap1 telomere 在 Role of Rap1 in DNA damage response 的相關結果
Mammalian Rap1 is a part of the telomere binding complex named shelterin and is one of the most conserved telomeric proteins. With its essential requirement ... ... <看更多>
rap1 telomere 在 Rap1, Rif1, and Rif2 inhibit resection at a de novo telomere in ... 的相關結果
Telomere length is associated with the proliferative potential of cells. Telomerase is an enzyme that elongates telomeres throughout the entire lifespan of an ... ... <看更多>
rap1 telomere 在 TRF2-interacting telomeric protein/Rap1, C ... - EMBL-EBI 的相關結果
This family of proteins represents the C-terminal domain of the protein Rap-1, which plays a distinct role in silencing at the silent mating-type loci and ... ... <看更多>
rap1 telomere 在 Identification of Human Rap1: Implications for Telomere ... 的相關結果
Identification of Human Rap1: Implications for. Telomere Evolution telomeres in budding yeast. Similarly, TIN2 and tankyr-. ... <看更多>
rap1 telomere 在 TRF2-RAP1 is required to protect telomeres from ... - NASA/ADS 的相關結果
Repressor/activator protein 1 (RAP1) is a highly conserved telomere-interacting protein. Yeast Rap1 protects telomeres from non-homologous end joining ... ... <看更多>
rap1 telomere 在 Loss of Rap1 induces telomere recombination in the absence ... 的相關結果
Abstract: Shelterin is an essential telomeric protein complex that prevents DNA damage signaling and DNA repair at mammalian chromosome ends. Here we... ... <看更多>
rap1 telomere 在 RAP1 at the Yeast Telomere | Lund University 的相關結果
Telomeres are specialized complexes of DNA and proteins that cap and ... from the RAP1 protein counting model of telomere length regulation. ... <看更多>
rap1 telomere 在 Literature citations | UniProt 的相關結果
This molecular Velcro relies on Rif1 and Rif2 to recruit and stabilize Rap1 on telomeric arrays and is required for telomere homeostasis in ... ... <看更多>
rap1 telomere 在 Loss of Rap1 Induces Telomere Recombination in ... - Science 的相關結果
However, Rap1 was critical for the repression of homology-directed repair (HDR), which can alter telomere length. The data reveal that HDR at ... ... <看更多>
rap1 telomere 在 3K6G: Crystal structure of Rap1 and TRF2 complex - RCSB PDB 的相關結果
Repressor activator protein 1 (RAP1) is the most highly conserved telomere protein. It is involved in protecting chromosome ends in fission ... ... <看更多>
rap1 telomere 在 The telomeric protein Rap1 is conserved in vertebrates and is ... 的相關結果
Abstract. We have identified the chicken homolog of the mammalian telomere protein repression and activation protein 1 (Rap1). Although cRap1 has only 36% ... ... <看更多>
rap1 telomere 在 Loss of Rap1 induces telomere recombination in ... - Addgene 的相關結果
Loss of Rap1 induces telomere recombination in the absence of NHEJ or a DNA damage signal. Sfeir A, Kabir S, van Overbeek M, Celli GB, de Lange T Science. ... <看更多>
rap1 telomere 在 Rif2 protects Rap1-depleted telomeres from MRX-mediated ... 的相關結果
Rap1 is the main protein that binds double-stranded telomeric DNA in Saccharomyces cerevisiae. Examination of the telomere functions of Rap1 is complicated ... ... <看更多>
rap1 telomere 在 Loss of Rap1 Induces Telomere Recombination in ... - JSTOR 的相關結果
Rapl was dispensable for the essential functions of TRF2 - repression of ATM kinase signaling and nonhomologous end joining (NHEJ) - and mice lacking telomeric ... ... <看更多>
rap1 telomere 在 Telomere-driven diseases and telomere-targeting therapies 的相關結果
In addition, mutations in telomere length maintenance genes and in ... Mammalian Rap1 controls telomere function and gene expression through binding to ... ... <看更多>
rap1 telomere 在 The DNA-Binding Domain of Yeast Rap1 Interacts with ... 的相關結果
Saccharomyces cerevisiae repressor-activator protein 1 (Rap1) is an ... (3, 9-11) At telomeres, Rap1 is involved in telomere-length ... ... <看更多>
rap1 telomere 在 Telomere-dependent and telomere-independent roles of ... 的相關結果
RAP1 is a well-known telomere-binding protein, but its functions in human stem cells have remained unclear. Here we generated RAP1-deficient human embryonic ... ... <看更多>
rap1 telomere 在 Rap1 prevents fusions between long telomeres in fission yeast 的相關結果
tion for species-specific upper limits on telomere length. Keywords end fusions; fission yeast; genome instability; Rap1; telomere. ... <看更多>
rap1 telomere 在 Telomere protein Rap1 is a charge resistant ... - UCL Discovery 的相關結果
In fission yeast, telomeres localise to the nuclear periphery via interaction of the telomeric protein Rap1 with the membrane protein Bqt4. During meiotic ... ... <看更多>
rap1 telomere 在 Rap1 in Candida albicans: an unusual structural organization ... 的相關結果
albicans RAP1 is not essential for cell viability but is critical for maintaining normal telomere length and structure. The rap1 null mutant ... ... <看更多>
rap1 telomere 在 Telomerase mutations in DC - UpToDate 的相關結果
DC: dyskeratosis congenita; TCAB1: telomere Cajal body associated protein 1 (gene: ... TERF1); TRF2: telomeric repeat-binding factor 2 (gene: TERF2); RAP1: ... ... <看更多>
rap1 telomere 在 TERF2IP Gene - TERF2 Interacting Protein - GeneCards 的相關結果
GeneCards Symbol: TERF2IP · TERF2 Interacting Protein · RAP1 · Telomeric Repeat-Binding Factor 2-Interacting Protein 1 · Dopamine Receptor-Interacting Protein 5 ... ... <看更多>
rap1 telomere 在 A genetic interaction between RAP1 and ... - Repisalud 的相關結果
Using genomewide ChIP sequencing, we find that progressive telomere shortening owing to telomerase deficiency leads to re-localization of RAP1 from telomeres ... ... <看更多>
rap1 telomere 在 TALEN gene knockouts reveal no requirement for the ... 的相關結果
The conserved protein Rap1 functions at telomeres in fungi, protozoa, and vertebrates. Like yeast Rap1, human Rap1 has been implicated in telomere length ... ... <看更多>
rap1 telomere 在 RAP1 Polyclonal Antibody (PA1-41267) 的相關結果
HRap1 is located at telomeres and affects telomere length by being recruited to telomeres by TRF2 instead of directly binding to the telomere like scRap1. The ... ... <看更多>
rap1 telomere 在 KU Paradox at Telomeres: Working Less - Institut Curie 的相關結果
DNA-bound telomere factors (i.e. TRF2, Taz1, Rap1) strongly inhibit NHEJ to ensure that chromosome ends do not fuse. On the other hand, the NHEJ factor KU ... ... <看更多>
rap1 telomere 在 Telomeres and metabolism - Biblos-e Archivo 的相關結果
Functional interplay between the telomere maintenance and mTOR pathways. Part 2. RAP1 role in chemically-induced hepatocellular carcinoma. Author. Ferrara Romeo ... ... <看更多>
rap1 telomere 在 Expression of Telomere-Associated Genes as Prognostic ... 的相關結果
Telomere dysfunction plays important roles in cancer initiation and progression. TRF1, TRF2, POT1, and RAP1 are four major telomere proteins ... ... <看更多>
rap1 telomere 在 RAP1/TERF2IP—A Multifunctional Player in Cancer ... - MDPI 的相關結果
RAP1 (TERF2IP) is a member of the shelterin complex that protects telomeric DNA and plays a critical role in maintaining chromosome stability. ... <看更多>
rap1 telomere 在 4bjt - Summary - Protein Data Bank Japan 的相關結果
4bjt: crystal structure of the rap1 c-terminal domain (rap1-rct) in ... Descriptor, DNA-BINDING PROTEIN RAP1, TELOMERE LENGTH REGULATOR PROTEIN RIF1, ... ... <看更多>
rap1 telomere 在 Anti-RAP1 antibody [4c8/1] (ab14404) - Abcam 的相關結果
Human Rap1 protein. Positive control. In Western Blot, this antibody gave a positive signal in the following whole cell lysates: HeLa; HEK293; ... ... <看更多>
rap1 telomere 在 C. albicans RAP1/C2_10080W SummaryLast curated 2023 ... 的相關結果
Description, Transcription factor; binds telomeres and regulatory sequences in DNA; involved in telomere maintenance; represses hyphal growth under ... ... <看更多>
rap1 telomere 在 Heart-Breaking Telomeres | Circulation Research 的相關結果
In addition, TPP1 is required for the recruitment of telomerase to chromosome ends in vivo (Figure 1C). Finally, RAP1 binds to telomeres via ... ... <看更多>
rap1 telomere 在 Telomere - Wikipedia 的相關結果
A telomere is a region of repetitive nucleotide sequences associated with specialized ... of six proteins identified as TRF1, TRF2, TIN2, POT1, TPP1, and RAP1. ... <看更多>
rap1 telomere 在 The Evolving Telomeres - 第 16 頁 - Google 圖書結果 的相關結果
Human Rap1 interacts directly with telomeric DNA and regulates TRF2 localization at the telomere. J. Biol. Chem. 287, 41583–41594. doi:10.1074/jbc. ... <看更多>
rap1 telomere 在 Microbial Genome Methods - 第 44 頁 - Google 圖書結果 的相關結果
as an antagonist of telomeric silencing , possibly by competing with SIR3 or SIR4 for association with RAP1.23,24,27 Genetic evidence has implicated an end ... ... <看更多>
rap1 telomere 在 Telomere: A Complex End of a Chromosome 的相關結果
It is composed by six different proteins: TRF1, TRF2, RAP1, TIN2, TPP1 and POT1 (upper panel of Figure 1] [2]. TRF1 (telomeric repeat binding factor 1, ... ... <看更多>
rap1 telomere 在 Telomerases: Chemistry, Biology, and Clinical Applications 的相關結果
to control both telomere function and gene expression via its binding to telomeric and nontelomeric sites. RAP1 also modulates NF-kB-mediated signaling (Teo ... ... <看更多>
rap1 telomere 在 Nucleic Acids and Molecular Biology 的相關結果
Gilson E, Müller T, Sogo J, Laroche T, Gasser SM (1994) RAP1 stimulates singleto double-strand association of yeast telomeric DNA: implications for ... ... <看更多>
rap1 telomere 在 Cellular Senescence and Tumor Suppression 的相關結果
Six proteins found at the telomere form the complex called shelterin; TRF1, TRF2, POT1, TPP1, RAP1, TIN2 (for an extended review see (de Lange 2005). ... <看更多>
rap1 telomere 在 Encyclopedia of Cell Biology - 第 424 頁 - Google 圖書結果 的相關結果
RAP1 protein interacts with yeast telomeres in vivo : Overproduction alters telomere structure and decreases chromosome stability . Cell 63 , 739-750 . ... <看更多>
rap1 telomere 在 20 links between sugar and cancer | CANCERactive 的相關結果
... actually promotes cancer via two pathways – EPAC/RAP1 and O-GicNAc. ... It concludes that 'short telomeres have been associated with the ... ... <看更多>
rap1 telomere 在 Molecular Themes in DNA Replication - 第 434 頁 - Google 圖書結果 的相關結果
... 128, 129, 229, 230 Rad53 checkpoint kinase 131, 300 Rap1 telomere-specific protein 221, 222 rate-limiting paired nucleotide conformational changes 97–8 ... ... <看更多>
rap1 telomere 在 Human RAP1 specifically protects telomeres of senescent ... 的相關結果
Repressor/activator protein 1 (RAP1) is a highly evolutionarily conserved protein found at telomeres. Although yeast Rap1 is a key telomere ... ... <看更多>