Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. Amanda J. Stock, Ross A. McDevitt, Chandrakala ... ... <看更多>
「rap1 shelterin」的推薦目錄：
rap1 shelterin 在 Shelterin - an overview | ScienceDirect Topics 的相關結果
The shelterin complex is made up of six family members that bind along the length of the telomere: TRF1 (TERF1), TRF2 (TERF2), RAP1 (TERF2IP), TIN2 (TINF2), ... ... <看更多>
rap1 shelterin 在 Shelterin: the protein complex that shapes and safeguards ... 的相關結果
They are interconnected by three additional shelterin proteins, TIN2, TPP1, and Rap1, forming a complex that allows cells to distinguish telomeres from ... ... <看更多>
rap1 shelterin 在 Shelterin - Wikipedia 的相關結果
Shelterin has six subunits: TRF1, TRF2, POT1, RAP1, TIN2, and TPP1. They can operate in smaller subsets to regulate the length of or to protect telomeres. TRF1 ... ... <看更多>
rap1 shelterin 在 RAP1 shelterin 蛋白的异常表达和定位导致与年龄相关的表型。 的相關結果
RAP1 shelterin 蛋白的异常表达和定位导致与年龄相关的表型。 短端粒诱导DNA 损伤反应(DDR)，引起人类细胞凋亡和衰老。一个现存的问题是端 ... ... <看更多>
rap1 shelterin 在 PomBase - protein coding gene - rap1 (SPBC1778.02) 的相關結果
02) - shelterin complex telomere binding subunit Rap1. Welcome to PomBase. A comprehensive database for the fission yeast Schizosaccharomyces pombe, providing ... ... <看更多>
rap1 shelterin 在 Shelterin is a dimeric complex with extensive structural ... 的相關結果
Human shelterin is a six-subunit complex—composed of TRF1, TRF2, Rap1, TIN2, TPP1, and POT1—that binds telomeres, protects them from the DNA-damage response, ... ... <看更多>
rap1 shelterin 在 RAP1/TERF2IP—A Multifunctional Player in Cancer ... - MDPI 的相關結果
RAP1 (TERF2IP) is a member of the shelterin complex that protects telomeric DNA and plays a critical role in maintaining chromosome stability. ... <看更多>
rap1 shelterin 在 MINI-REVIEW Shelterin Proteins and Cancer - KoreaScience 的相關結果
TPP1 and RAP1, enabling cells distinguish telomeres from other sites of DNA damage in the genome (Titia de Lange, 2005). Shelterin blocks three major ... ... <看更多>
rap1 shelterin 在 Human RAP1 specifically protects telomeres of senescent ... 的相關結果
Finally, RAP1, one of the most evolutionarily conserved shelterin proteins, binds to telomeric DNA via its interaction with TRF2 12. ... <看更多>
rap1 shelterin 在 What I got wrong about shelterin 的相關結果
Shelterin protects telomeres from all aspects of the DNA damage response, ... telomere · shelterin · Ras-related protein 1 (Rap1) · POT1 ... ... <看更多>
rap1 shelterin 在 RAP1 Protects from Obesity through Its Extratelomeric Role ... 的相關結果
RAP1 is part of shelterin, the protective complex at telomeres. RAP1 also binds along chromosome arms, where it is proposed to regulate gene expres-. ... <看更多>
rap1 shelterin 在 Telomere protein RAP1 levels are affected by cellular aging ... 的相關結果
Shelterin is a six-member protein complex that associates with telomeric DNA in mammals [reviewed in (3)]. In cells with telomerase activity, ... ... <看更多>
rap1 shelterin 在 B6;129-Terf2ip tm1.1Tdl /J - The Jackson Laboratory 的相關結果
012346 B6;129-Terf2ip tm1.1Tdl /J These Rap1 F mice harbor loxP sites ... As Rap1 is one of the components of shelterin, these Rap1 F mutant mice may be ... ... <看更多>
rap1 shelterin 在 RAP1 - DNA-binding protein RAP1 | UniProtKB | UniProt 的相關結果
RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM ... Cellular Component, shelterin complex ... <看更多>
rap1 shelterin 在 About 1 — de Lange Laboratory 的相關結果
Shelterin is composed of six proteins: TRF1, TRF2, Rap1, TIN2, TPP1, and POT1. TRF1 and TRF2 bind to the duplex telomeric repeat array and anchor shelterin on ... ... <看更多>
rap1 shelterin 在 Shelterin Complex at Telomeres: Implications in Ageing | CIA 的相關結果
In human cells, the shelterin complex is composed of six proteins, including TRF1, TRF2, POT1, RAP1, TIN2 and TPP1 (Figure 1). ... <看更多>
rap1 shelterin 在 cooperative assembly of shelterin bridge provides a kinetic ... 的相關結果
pombe shelterin complex. Rap1, Poz1, and Tpz1 connect double-stranded and single-stranded telomeric DNA binding proteins, Taz1 and Pot1, ... ... <看更多>
rap1 shelterin 在 Structure of the fission yeast S. pombe telomeric Tpz1-Poz1 ... 的相關結果
pombe shelterin complex is also composed of six proteins — Taz1, Rap1, Poz1, Tpz1, Pot1, and Ccq1. Taz1 binds directly to the double-stranded ... ... <看更多>
rap1 shelterin 在 The Role of Shelterin Complex and Post-Translational Non ... 的相關結果
The Role of Shelterin Complex and Post-Translational ... proteins including but not limited to shelterin complex(TRF1, TRF2, RAP1, TIN2, ... ... <看更多>
rap1 shelterin 在 Loss of Rap1 Induces Telomere Recombination in ... - Science 的相關結果
Shelterin is an essential telomeric protein complex that prevents DNA damage signaling and DNA repair at mammalian chromosome ends. ... <看更多>
rap1 shelterin 在 TALEN gene knockouts reveal no requirement ... - eScholarship 的相關結果
Like yeast Rap1, human Rap1 has been implicated in telomere length regulation and ... Loss of Rap1 did not affect the other components of shelterin, ... ... <看更多>
rap1 shelterin 在 shelterin complex | SGD - Saccharomyces Genome Database 的相關結果
The complex is known to contain TERF1, TERF2, POT1, RAP1, TINF2 and ACD in mammalian cells, and Pot1, Tpz1, Rap1, Rif1, Rif2 and Taz1 in Saccharomyces. ... <看更多>
rap1 shelterin 在 Anti-RAP1 antibody [4c8/1] (ab14404) - Abcam 的相關結果
Mouse monoclonal RAP1 antibody [4c8/1]. Validated in WB, IP, Flow Cyt and tested in Human. Cited in 6 publication(s). Independently reviewed in 4 review(s). ... <看更多>
rap1 shelterin 在 Aberrant expression and localization of the RAP1 ... - ebsco 的相關結果
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. Language: English; Authors: Stock, Amanda J. 1 (AUTHOR) ... <看更多>
rap1 shelterin 在 TRF2-interacting telomeric protein/Rap1, C-terminal ... 的相關結果
Rap1 is otherwise known as TRF2-interacting protein, as it is one of the six subunit components of the Shelterin complex. Shelterin protects telomere ends ... ... <看更多>
rap1 shelterin 在 4RQI: Structure of TRF2/RAP1 secondary interaction binding site 的相關結果
In human, the shelterin complex binds TTAGGG DNA repeats and provides capping to chromosome ends. Within shelterin, RAP1 is recruited ... ... <看更多>
rap1 shelterin 在 Design of High-Affinity Stapled Peptides To Target the ... 的相關結果
Repressor activator protein 1 (RAP1) and telomeric repeat-binding factor 2 (TRF2) are two subunits in shelterin that interact with each ... ... <看更多>
rap1 shelterin 在 TERF2IP Gene - TERF2 Interacting Protein - GeneCards 的相關結果
GeneCards Symbol: TERF2IP; TERF2 Interacting Protein; RAP1 ... In contrast to other components of the shelterin complex, it is dispensible ... ... <看更多>
rap1 shelterin 在 The structural biology of the shelterin complex - De Gruyter 的相關結果
Mammalian telomeres are bound by shelterin, a specialized six-protein complex that consists of TRF1, TRF2, RAP1, TIN2, TPP1 and POT1 ... ... <看更多>
rap1 shelterin 在 Biochemical and structural analysis of shelterin subcomplexes 的相關結果
Structures of TRF2-RAP1-TIN2S and POT1-TPP1-TIN2S obtained through negative stain electron microscopy (EM) are presented. Cryo-EM imaging of DNA and nucleosome ... ... <看更多>
rap1 shelterin 在 Role of Rap1 in DNA damage response 的相關結果
Mammalian Rap1 is a part of the telomere binding complex named shelterin and is one of the most conserved telomeric proteins. With its essential requirement ... ... <看更多>
rap1 shelterin 在 Heregulin, a new interactor of the telosome/shelterin complex ... 的相關結果
Analysis of protein-protein interactions using a high-throughput yeast two-hybrid (Y2H) screen identified RAP1, the only telomere protein that is conserved ... ... <看更多>
rap1 shelterin 在 Investigation into the role of human RAP1 in telomere protection 的相關結果
In mammals, the shelterin complex is the guardian of telomere stability. It operates through a set of six proteins (TRF1, TRF2, POT1, RAP1, TPP1 and TIN2) ... ... <看更多>
rap1 shelterin 在 Rif2 protects Rap1-depleted telomeres from MRX-mediated ... 的相關結果
Telomere-specific depletion of Rap1, the main sequence-specific ... (2010a) Shelterin-Like Proteins and Yku Inhibit Nucleolytic Processing ... ... <看更多>
rap1 shelterin 在 C. albicans RAP1/C2_10080W SummaryLast curated 2023 ... 的相關結果
RAP1 BASIC INFORMATION [ View References ] ... nucleus (IEA with S. cerevisiae: RAP1) * shelterin complex (IEA with S. cerevisiae: RAP1) ... ... <看更多>
rap1 shelterin 在 The telosome/shelterin complex and its functions 的相關結果
The length of telomeric DNA is maintained by the enzyme telomerase, but in addition, six telomere-associated proteins - TRF1, TRF2, POT1, RAP1, ... ... <看更多>
rap1 shelterin 在 Investigating Mechanisms of Telomere End-Protection 的相關結果
Mammalian Rap1 interacts with shelterin factor TRF2, to localize to telomeres, and human Rap1 is implicated in repressing NHEJ. Surprisingly, removal of ... ... <看更多>
rap1 shelterin 在 Rap1 Affects the Length and Heterogeneity of Human ... 的相關結果
In budding yeast, the major telomere length regulator scRap1 binds to telomeric DNA and acts to inhibit telomere elongation in cis. Because the human Rap1 ... ... <看更多>
rap1 shelterin 在 Casein kinase 2 regulates telomere protein complex formation ... 的相關結果
Taz1 recruits Rap1 to telomeres, which in turn interacts with Poz1 to form the shelterin com- plex, which regulates telomere DNA length and ... ... <看更多>
rap1 shelterin 在 Shelterin Proteins and Cancer 的相關結果
... sequence boundwith specialised protein complex called the “shelterin complex”. It comprises six proteins, namely TRF1, TRF2,TIN2, POT1, TPP1 and RAP1. ... <看更多>
rap1 shelterin 在 A genetic interaction between RAP1 and telomerase reveals ... 的相關結果
Summary RAP1 is one of the components of shelterin, the capping complex at chromosome ends or telomeres, although its role in telomere ... ... <看更多>
rap1 shelterin 在 Prognostic significance of dysregulation of shelterin complex ... 的相關結果
RAP1 (P = 0.020) and hTERT (P = 0.037) displayed to be independent prognostic markers for overall survival. Clinical parameters and genes were ... ... <看更多>
rap1 shelterin 在 Telomere Recognition and Assembly Mechanism of ... 的相關結果
Although the entire shelterin complex consists of TRF1, TRF2, Rap1, TIN2, TPP1 and POT1, sub-complexes lacking TRF1 or TRF2/Rap1 can engage telomeres in ... ... <看更多>
rap1 shelterin 在 A biochemical analysis of human shelterin complexes 的相關結果
The human shelterin complex is a dynamic assembly of six components, consisting of TRF1, TRF2, RAP1, TIN2, TPP1, and POT1. ... <看更多>
rap1 shelterin 在 Purified anti-RAP1 Antibody - BioLegend 的相關結果
Repressor/activator protein 1 (RAP1), also called telomeric ... RAP1 forms a heterodimer with shelterin subunit TRF2 and regulates telomere ... ... <看更多>
rap1 shelterin 在 Telomere-dependent and telomere-independent roles of ... 的相關結果
RAP1 is a well-known telomere-binding protein, but its functions in ... Human shelterin is composed of six components: RAP1, TRF1, TRF2, ... ... <看更多>
rap1 shelterin 在 Zscan4 interacts directly with human Rap1 in cancer cells ... 的相關結果
Telomeres are repetitive sequences at the ends of chromosomes protected by DNA binding proteins of the shelterin complex that form capping ... ... <看更多>
rap1 shelterin 在 The structural biology of the shelterin complex 的相關結果
Rap1 proteins in fission yeast and mammalian cells also contain one or two Myb domains, but they do not have any DNA-binding activity. On the ... ... <看更多>
rap1 shelterin 在 Publications | LifeB 的相關結果
Quantitative Biology of Human Shelterin and Telomerase: Searching for the ... of telomere guardian TRF2 reduces D-loop unwinding whereas RAP1 restores it. ... <看更多>
rap1 shelterin 在 TALEN Gene Knockouts Reveal No Requirement for the ... 的相關結果
Rap1 is a component of shelterin, the protein complex that functions to protect telomeres, recruits telomerase, and regulates telomere length (reviewed in ... ... <看更多>
rap1 shelterin 在 Telomere recognition and assembly mechanism of ... - CORE 的相關結果
DNA binding proteins, and the sixth subunit, Rap1, is associated with TRF2. Although the entire shelterin complex consists of TRF1, TRF2, ... ... <看更多>
rap1 shelterin 在 Heregulin, a new interactor of the telosome ... - Oncotarget 的相關結果
Deletion analysis of RAP1 revealed that the linker domain, a region previously suggested to recruit negative regulators of telomere length, ... ... <看更多>
rap1 shelterin 在 Research resolves contradiction over protein's role at telomeres 的相關結果
Rap1 is one of six shelterin components in humans and mice, and one that evolution has maintained for a very long time, all the way back to ... ... <看更多>
rap1 shelterin 在 The shelterin complex and hematopoiesis - JCI 的相關結果
The shelterin complex consists of six proteins (TRF1, TRF2, RAP1, TIN2, POT1, and TPP1) that bind the double-stranded and single-stranded ... ... <看更多>
rap1 shelterin 在 3k6g - Proteopedia, life in 3D 的相關結果
... TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. ... <看更多>
rap1 shelterin 在 Shelterin genes, germ line mutations and chronic lymphocytic ... 的相關結果
Shelterin genes, germ line mutations and chronic lymphocytic leukemia. ... Human RAP1 inhibits non-homologous end joining at telomeres. ... <看更多>
rap1 shelterin 在 RAP1 antibody (ABIN4914570) 的相關結果
In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against ... ... <看更多>
rap1 shelterin 在 TERF2IP (D9H4) Rabbit mAb#5433 - Cell Signaling Technology 的相關結果
Telomeric repeat-binding factor 2-interacting protein (TERF2IP, also known as RAP1) is a component of the Shelterin Complex, a multi-protein complex that ... ... <看更多>
rap1 shelterin 在 RAP1 Antibody (4C8/1) | SCBT - Santa Cruz Biotechnology 的相關結果
RAP1 Antibody (4C8/1) is an IgG2b κ mouse monoclonal TERF2IP antibody that detects m, r, and h RAP1 by WB, IP, IF and IHC(P). 13 citations. ... <看更多>
rap1 shelterin 在 Shelterin Database 的相關結果
The shelterin complex is composed by six proteins named TRF1, TRF2, RAP1, TPP1, POT1 and TIN2, which prevents telomeres from degradation or fusion. ... <看更多>
rap1 shelterin 在 Shelterin-Mediated Telomere Protection - De Lange lab 的相關結果
Human shelterin consists of six distinct proteins, TRF1, TRF2, Rap1, TIN2, TPP1, and a single version of POT1 (Figure 1a,d) (32). ... <看更多>
rap1 shelterin 在 Telomerases: Chemistry, Biology, and Clinical Applications 的相關結果
... Negatively H. sapiens TRF1 Shelterin Yes (ds) n.a. Negatively TRF2 Shelterin Yes (ds) n.a. Negatively RAP1 Shelterin No TRF2 Negatively TIN2 Shelterin ... ... <看更多>
rap1 shelterin 在 Intracellular Signaling Mediators in the Circulatory and ... 的相關結果
Small Rap1 GTPase is a member of the shelterin complex, or telosome complex, that regulates the length of telomeres and protects chromosome ends [909].123 ... ... <看更多>
rap1 shelterin 在 DNA Replication Controls: Volume 2 - 第 45 頁 - Google 圖書結果 的相關結果
shelterin complex prevents chromosomal fusions resulting from improper ... RNA TIN2 TPP1 POT1 TRF1 TRF2 3' RAP1 Shelterin RTEL1 WRN UPF1 Apollo WRN RTEL1 ... ... <看更多>
rap1 shelterin 在 Ubiquitin and Ubiquitin-Relative SUMO in DNA Damage Response 的相關結果
FIGURE 1 | Shelterin components and their functions in telomere protection. ... TRF2 interacts with the shelterin component RAP1 and recruits ... ... <看更多>
rap1 shelterin 在 Postgraduate Haematology - 第 194 頁 - Google 圖書結果 的相關結果
... 5' TRF1 TRF2/RAP1 Shelterin Dyskerin: hemizygous mutations cause X-linked ... NHP2, NOP10, TERC and TERT), the shelterin complex and their association ... ... <看更多>
rap1 shelterin 在 Aberrant expression and localization of the RAP1 shelterin ... 的相關結果
Aberrant expression and localization of the RAP1 shelterin protein contribute to age-related phenotypes. PLoS Genet. ... <看更多>