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Composed of 95% naturally-derived ingredients*, Abeille Royale Advanced Youth Watery Oil harnesses the very best that nature has to offer. Each bee ingredient is carefully selected according to Guerlain Research’s three key criteria: an unspoilt environment, abundant biodiversity and the genetic profile of the bee.
*Calculation based on the international ISO standard 16128, including water. The remaining 5% contribute to optimising the formula's integrity over time and its sensorial texture.
今晚直播目錄出爐囉～
1:39 先更正上次斗內大德無名支持者部份我陳述內容：我談論美國欠中國債務，其實是中國政府欠美國的債務，我搞反了，請注意！以下是相關新聞：https://reurl.cc/bz9R9l）
6:33 PArt One續談疫苗
14:40 一個正確的病毒需要分離（isolation）、純化（purification）與編碼（characterization）
問題是目前的Sars-Cov-2病毒，連上面一個都不符合
上次講了老共的吳尊友說「they didn’t isolate the virus」
-又再吵是否可進AZ、BNT疫苗；剛好都是歐洲疫苗，就看看當地專家如何說
21:56 去年1月德國出過一件報告，說德國病毒國濕Christian Drosten病毒檢測模式，沒有根據「Sars-Cov-2病毒」？？！！哈囉，那你的檢測是怎出來的？
https://www.eurosurveillance.org/content/10.2807/1560-7917.ES.2020.25.3.2000045
https://retractionwatch.com/2020/12/07/public-health-journal-seeking-further-expert-advice-on-january-paper-about-covid-19-pcr-testing-by-high-profile-virologist/
內文：In the present case of 2019-nCoV, virus isolates or samples from infected patients have so far not become available to the international public health community. ... Design and validation were enabled by the close genetic relatedness to the 2003 SARS-CoV, and aided by the use of synthetic nucleic acid technology.
26:30 再看看美國，CDC去年7月在報告中第42頁說：Since no quantified virus isolates of the 2019-nCoV are currently available, assays designed for detection of the 2019-nCoV RNA were tested with characterized stocks of in vitro transcribed full length RNA
https://www.fda.gov/media/134922/download
-就是說美國人也是找山寨版新冠調配PCR測試啦！
-換言之，疫苗大國的中國、美國與德國都說「其實啊，我們根本沒找到病毒」
-那疫苗是打啥的？
-我都提供莒光論述喔，現在換你們說服我！
-然後一堆人打疫苗後死掉、頭暈，還不能不打！
-大濕原則：「不進口、不施打、不跟風」
-目前病毒已非重點、疫苗才是
-電子貨幣、繳學費
37:30 PArt Two 不存在的武統與貿易戰
-新內閣要開啟兩岸大門耶！邱太三
-問題是去年哪有抗爭？看看GDP、出口量；全球唯二正值都為華人區域，WHY？
-沒武統、只有暗統
-旺報為何幫美爸刊軍購新聞？
45:00 北京修改香港選制，感謝川建國與黃捷
47:31 奇怪，川普已走，為何不取消關稅，原來....
-奇怪，tsmc怎還不去美國？
PArt Three 其它國內外議題
53:50 為進口洋垃圾、這群低階人口反遭殃
58:02 拜登要防止暖化，請問美國是否為冰化？
-聽說有人微波雪，反會爆炸？
PArt Four 財經議題
1:12:30 Fed何時升息？
1:15:24 黃金與美元大貶值？
1:21:49 台幣升值與荷蘭（唬爛）病
1:26:30 比特幣、GameStop、美國十年期公債殖利率、主力在想什麼
你斗內、我回答：
1:32:35 感謝斗內大德王先生說：上次希望大師小聲點，雖然現在有改善很多但大師變得太拘謹了 還是以前幽默風趣談笑風生的大師比較對味。我現在改用耳機聽了
-哈哈，我們一起適應啦，我也要保存中氣
-感謝
1:37:32 感謝斗內大德小道姊說：請回顧電影出神入化Now+You+See+Me作為社會上許多問題的解方，老魔術師將牌藏在樹中20年。真正大型的魔術當屬金錢的製造流程，每月付帳單的當下精心的試算資產負債餘額，卻從不質疑金錢的製造過程。
-眼睛是重點
-氣候變遷，agenda 21藏了30年迄今
-最後玩貨幣重整
感謝斗內大德CW說：純donate+
1:44:36 感謝斗內大德匿名者說：大師的一小時節目計劃進度如何了？在節目優化這方面有沒有什麼想法？最近很多人在用的clubhouse有安排要進駐嗎？有時對大師的直播有些建議，但想用匿名的方式，有其他方式可以匿名提供個人意見嗎？
感謝斗內YT大德Thomas LEE小額贊助大師，幫助頻道推播，大家新年快樂。
感謝斗內YT大德Taisheng Huang
感謝斗內YT大德Rocky You
直播網址：https://youtu.be/P8J927FN9GU
優質內容，需要您們的贊助！
贊助連結: https://p.ecpay.com.tw/B7CB5 （留言不可空格、分段）
在臉書河道看到的一篇文章，發文的人翻譯了一則外國人的發文：
https://m.facebook.com/story.php?story_fbid=10158846902129328&id=602809327
我有在外國人的發文底下留言，可惜不能在這個翻譯的人底下留言，所以我打在這邊。
首先 #疫苗 是什麼？這個google很容易，高中生物應該也有提過，疫苗的發展大約兩百年，前一百年只有不活化疫苗和減毒疫苗，後一百年才陸續研發了純化蛋白疫苗以及基因工程疫苗等等。
再來了解疫苗的分類：
#活疫苗 有不活化與減毒活疫苗、異質性活疫苗（例如牛痘）
#死疫苗 有死毒疫苗、死菌疫苗、次單位疫苗（細分 類毒素疫苗、基因工程重組蛋白疫苗、胜肽疫苗、基因轉殖植物性疫苗、基因型疫苗或抗基因型抗體）、多核苷或DNA疫苗、載體疫苗、標記疫苗、mRNA疫苗（近十年嶄新研究）。
（附上大學課本疫苗發展與實驗內頁比較圖)
基因疫苗自1992年首次在科學文獻報告至今，已經成為最熱門的疫苗研究新方向，目前包括傳染性疾病、癌症、過敏症與自體免疫性疾病，以廣泛進行基因疫苗的臨床前或臨床研究並獲得良好的結果。
發文的人顯然不懂疫苗有分活疫苗跟死疫苗，也不懂mRNA疫苗不等於活疫苗，應該也不懂免疫學。
這篇錯誤訊息蠻多的，可以參考國衛院的說明
https://forum.nhri.org.tw/covid19/j_translate/j2022/
當年大學學習時就知道了，疫苗的研發與應用的智慧，基因疫苗的作用原理與傳統疫苗不同。
傳統死毒疫苗或者重組蛋白疫苗，病毒抗原是由體外注射到人體，經由巨噬細胞等抗原呈現細胞（APC cell)吞噬後，被分解的抗原片段經MHC2（組織相容性複合體第二型）呈現給T cell。此種免疫反應是以引發輔助T cell，產生抗體為主的免疫反應。
而基因疫苗是在進入細胞後於細胞質表現抗原蛋白，這些內生性蛋白有部分會被酵素分解成蛋白片段，在內質網和MHC1結合以後呈現在細胞膜上，藉此和殺手T細胞表面受器結合，活化殺手T細胞，引發細胞毒殺作用。
基因疫苗也能引發MHC2抗體反應，因此基因疫苗可以同時引發抗體反應和殺手T細胞反應。
2018年發表的文獻指出mRNA疫苗的優點：
Over the past decade, major technological innovation and research investment have enabled mRNA to become a promising therapeutic tool in the fields of vaccine development and protein replacement therapy. The use of mRNA has several beneficial features over subunit, killed and live attenuated virus, as well as DNA-based vaccines. First, safety: as mRNA is a non-infectious, non-integrating platform, there is no potential risk of infection or insertional mutagenesis. Additionally, mRNA is degraded by normal cellular processes, and its in vivo half-life can be regulated through the use of various modifications and delivery methods. The inherent immunogenicity of the mRNA can be down-modulated to further increase the safety profile. Second, efficacy: various modifications make mRNA more stable and highly translatable. Efficient in vivo delivery can be achieved by formulating mRNA into carrier molecules, allowing rapid uptake and expression in the cytoplasm (reviewed in Refs 10,11). mRNA is the minimal genetic vector; therefore, anti-vector immunity is avoided, and mRNA vaccines can be administered repeatedly. Third, production: mRNA vaccines have the potential for rapid, inexpensive and scalable manufacturing, mainly owing to the high yields of in vitro transcription reactions.
1. 安全性，非感染性活體病毒，沒有潛在感染跟插入誘導基因改變的風險。
2. 穩定且可製成載體進入細胞質中，屬於最小的mRNA載體。（過往的基因疫苗都是需要plasmid DNA載體DNA，多一個步驟。）
3. 沒有抗載體的免疫反應，因此不用擔心anti-vector immunity。不會有過敏或者自體免疫產生。
4. 生產也很便利快速。
美國食品與藥物管理局特別針對基因疫苗的安全性、潛力與免疫能力制定相關規定，”Points to Consider on Plasmid DNA Vaccines for Preventive Infections Disease Indication”，作為研究基因疫苗時的參考指標。
相關文獻references:
1. Donnelly,J.J.,J.B. Ulmer, J.W. Shiver, and M.A. Liu. 1997. DNA vaccines. Annu. Rev. Immunol. 15:617-48.
2. Cytotoxic T-lymphocyte-, and helper T-lymphocyte-oriented DNA vaccination
Toshi Nagata et al. DNA Cell Biol. 2004 Feb.
https://pubmed.ncbi.nlm.nih.gov/15000749/
3. mRNA vaccines — a new era in vaccinology
https://www.nature.com/articles/nrd.2017.243
Today, I am going to show you my Circle DNA Test Result specifically on Sports & Fitness, Optimal Training Type.
According to my Circle DNA Test Result, which I can see on the app:
Consider the following:
Based on your genetic results, you have an even split between power, endurance and strength. You could benefit from training evenly across these training types.
For muscle development use high volumes at low intensities such as sets of 15-20 reps with 60 seconds rest completed 3 times. Engage in steady state training to develop fitness, an example of this is continuous cardiovascular exercise such as cycling or running for 30 minutes or more.
About Optimal Training Type
Evidence shows that how we respond to exercise is influenced by genetics. It won't be the whole picture alone, but it will be a part of the picture. Variations in our genetic profile can help explain why some people see a better response to different types of exercise. Following a genetically-guided exercise program has shown up to three fold improvements in training compared to genetically mismatched training.
Remember
This is a look at how your genetic profile might affect the rate at which you respond to different intensities of exercise, this should not be used to change your goal, but may help better personalise your most effective route to achieving that goal.
#CircleDNA
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If you haven't seen our overview video on Okinawa:
https://www.youtube.com/watch?v=1S3Pmi00hKg
Thanks to Odigo Travel for sending us to Okinawa!!
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Life has no limits! Get out there and do something new today!
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genetic profile 在 Biology: DNA Profiling - YouTube 的推薦與評價
We ease into this video with a general explanation of what DNA profiling is. Then, we look at two main ways of constructing a DNA profile : ... ... <看更多>